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ScienceDaily: Top Health News

ScienceDaily: Top Health News


A scientific first: How psychedelics bind to key brain cell receptor

Posted: 17 Sep 2020 03:12 PM PDT

For the first time, scientists solved the high-resolution structure of these compounds when they are actively bound to the 5-HT2A serotonin receptor on the surface of brain cells. This discovery is already leading to the exploration of more precise compounds that could eliminate hallucinations but still have strong therapeutic effects. Psilocybin - the psychedelic compound in mushrooms - has already been granted breakthrough status by the FDA to treat depression.

Scientists discover what happens in our brains when we make educated guesses

Posted: 17 Sep 2020 03:12 PM PDT

Researchers have identified how cells in our brains work together to join up memories of separate experiences, allowing us to make educated guesses in everyday life. By studying both human and mouse brain activity, they report that this process happens in a region of the brain called the hippocampus.

Curve at tip of shoes eases movement but may lead to weaker muscles, problems

Posted: 17 Sep 2020 03:12 PM PDT

The scientists found that the more curved a toe spring is, the less power the foot inside the shoe has to exert when pushing off from the ground while walking. That means foot muscles are doing less work, and this, the researchers hypothesize, may have consequences such as less endurance and make people more susceptible to medical conditions like plantar fasciitis.

Higher dementia risk in women with prolonged fertility

Posted: 17 Sep 2020 07:54 AM PDT

Women with a longer reproductive period had an elevated risk for dementia in old age, compared with those who were fertile for a shorter period, a population-based study.

Time-restricted feeding improves health without altering the body's core clock

Posted: 17 Sep 2020 07:54 AM PDT

For the first time, scientists have studied the early effects of time-restricted feeding on the daily periodic oscillations of metabolites and genes in muscle, and metabolites in blood. The findings find that time-restricted feeding does not influence the muscle's core clock, and opens the door to more research on how these observed changes improve health.

Engineered bacteria churn out cancer biomarkers

Posted: 17 Sep 2020 07:54 AM PDT

Pity the glycan. A lab has created these very tools by commandeering simple, single-celled microorganisms - namely E. coli bacteria - and engineering them to explore the complex process of glycosylation and the functional role that protein-linked glycans play in health and disease.

New cause of syndromic microcephaly identified

Posted: 17 Sep 2020 07:54 AM PDT

A team of international collaborators identifies a new cause of syndromic microcephaly caused by LMNB1 mutations that disrupt the nuclear envelope.

Why the dose matters: Study shows levels and anti-tumor effectiveness of a common drug vary widely

Posted: 17 Sep 2020 07:53 AM PDT

When used to manage infections, the drug itraconazole is generally given at a single, fixed dose to all patients. But determining the correct dosage of the drug to help treat cancer isn't that simple, new research suggests.

Potential target identified for migraine therapy

Posted: 17 Sep 2020 07:53 AM PDT

Researchers have identified the protein GLT-1 as the neurotransmitter glutamate transporter in the brain that is related to cortical spreading depression, a pathological condition that underlies migraines. The researchers found that mice lacking GLT-1, but not other glutamate receptors, were more susceptible to cortical spreading depression than were controls. GLT-1 might therefore be a potential target for migraine therapy.

Mathematical modelling to prevent fistulas

Posted: 17 Sep 2020 07:53 AM PDT

It is better to invest in measures that make it easier for women to visit a doctor during pregnancy than measures to repair birth injuries. This is the conclusion from mathematicians, using Uganda as an example.

Metformin for type 2 diabetes patients or not? Researchers now have the answer

Posted: 17 Sep 2020 07:53 AM PDT

Metformin is the first-line drug that can lower blood sugar levels in type 2 diabetes patients. One third of patients do not respond to metformin treatment and 5 per cent experience serious side effects, which is the reason many choose to stop medicating. Researchers have now identified biomarkers that can show in advance how the patient will respond to metformin treatment via a simple blood test.

Smoking linked to bleeding in the brain in large, long-term study of twins

Posted: 17 Sep 2020 05:45 AM PDT

Researchers in Finland found a link between smoking and subarachnoid hemorrhage (SAH), a type of bleeding stroke, in a study of more than 16,000 pairs of twins over 42 years. The study found that bleeding in the brain can be explained to a greater degree by environmental risk factors, such as smoking, than by genetic influence.

Improving the efficacy of cellular therapies

Posted: 17 Sep 2020 05:45 AM PDT

A new study deepens the understanding of the development of T cell, an important component of the immune system.

Live imaging method brings structural information to mapping of brain function

Posted: 17 Sep 2020 05:41 AM PDT

Neuroscientists distinguish brain regions based on what they do, but now have a new way to overlay information about how they are built, too.

Children who take steroids at increased risk for diabetes, high blood pressure, blood clots

Posted: 17 Sep 2020 05:41 AM PDT

Children who take oral steroids to treat asthma or autoimmune diseases have an increased risk of diabetes, high blood pressure, and blood clots, according to new researchers. The study is the first to quantify these complications of oral steroids in a nationwide population of children.

Typhoid: Study confirms Vi-DT conjugate vaccine is safe and immunogenic in children 6-23 months

Posted: 17 Sep 2020 05:40 AM PDT

A new study shows that single-dose and two-dose regimens of Vi-DT typhoid conjugate vaccine (TCV) are safe and immunogenic in children 6-23 months of age, a group with high rates of typhoid fever in resource-limited settings.

The key to happiness: Friends or family?

Posted: 17 Sep 2020 05:40 AM PDT

Think spending time with your kids and spouse is the key to your happiness? You may actually be happier getting together with your friends, a new study finds.

New smart drug delivery system may help treatment for neurological disorders

Posted: 17 Sep 2020 05:40 AM PDT

A research team has created a smart drug delivery system that reduces inflammation in damaged nervous tissues and may help treat spinal cord injuries and other neurological disorders. The system, which uses extremely thin biomaterials implanted in the body, also protects nerve fibers (axons) that connect nerve cells in injured neural tissues, according to a new study.

New gene implicated in neuron diseases

Posted: 16 Sep 2020 12:48 PM PDT

Failures in a quality control system that protects protein-building fidelity in cells can lead to motor neuron degeneration and related diseases, according to a new study shows.

Discoveries made in how immune system detects hidden intruders

Posted: 16 Sep 2020 12:48 PM PDT

Research has led to better understanding on how components of the body's immune system find intruding or damaged cells, which could lead to novel approaches to viral and cancer treatments.

A ferry protein in the pancreas protects it from the stress induced by a high-fat diet

Posted: 16 Sep 2020 10:10 AM PDT

Scientists have now uncovered a key mechanism by which pancreatic function is maintained in response to a high-fat diet. A protein present in pancreatic insulin-producing cells protects them from damage under the stress induced by a high-fat diet. As the world increases its intake of high-fat foods and as type 2 diabetes incidence rises as a result, this protein could be a novel therapeutic target for type 2 diabetes mellitus.

Perfectionists may be more prone to helicopter parenting

Posted: 16 Sep 2020 10:10 AM PDT

The negative effects of over-parenting on children are well documented, but less is known about why certain people become helicopter parents. A new study suggests perfectionism is one driver.

Injectable hydrogel could someday lead to more effective vaccines

Posted: 16 Sep 2020 06:05 AM PDT

Vaccines have curtailed the spread of several infectious diseases, such as smallpox, polio and measles. However, vaccines against some diseases, including HIV-1, influenza and malaria, don't work very well, and one reason could be the timing of antigen and adjuvant presentation to the immune system. Now, researchers have developed an injectable hydrogel that allows sustained release of vaccine components, increasing the potency, quality and duration of immune responses in mice.

Extremely social robotic fish helps unravel collective patterns of animal groups

Posted: 15 Sep 2020 04:42 PM PDT

Using state-of-the-art robotics, a research team shows that animals' speed is fundamental for collective behavioral patterns, and that ultimately it is the faster individuals that have the strongest influence on group-level behavior.

Loneliness predicts development of type 2 diabetes

Posted: 15 Sep 2020 07:59 AM PDT

New research has shown for the first time that people over 50 who report higher levels of loneliness are more likely to develop type 2 diabetes later in life.